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Plos Genetics : Recombination Hotspots Flank the Cryptococcus Mati...

By: Susan Dutcher

Description : Recombination increases dramatically during meiosis to promote genetic exchange and generate recombinant progeny. Interestingly, meiotic recombination is unevenly distributed throughout genomes, and, as a consequence, genetic and physical map distances do not have a simple linear relationship. Recombination hotspots and coldspots have been described in many organisms and often reflect global features of chromosome structure. In particular, recombination fre...

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Plos Genetics : Cytoplasmic Streaming in Neurospora ; Disperse the...

By: Susan K. Dutcher
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Plos Genetics : Methylated H3K4, a Transcription-associated Histon...

By: Gregory P. Copenhaver

Description : Eukaryotic genomes are associated with a number of proteins such as histones that constitute chromatin. Post-translational histone modifications are associated with regulatory aspects executed by chromatin and all transactions on genomic DNA are dependent on them. Thus, it will be relevant to understand how histone modifications affect genome functions. Here we show that the mono ubiquitylation of histone H2B and the tri-methylation of histone H3 on lysine ...

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Plos Genetics : Karyotypic Determinants of Chromosome Instability ...

By: Beth A. Sullivan

Description : Recent studies in cancer cells and budding yeast demonstrated that aneuploidy, the state of having abnormal chromosome numbers, correlates with elevated chromosome instability (CIN), i.e. the propensity of gaining and losing chromosomes at a high frequency. Here we have investigated ploidy- and chromosome-specific determinants underlying aneuploidy-induced CIN by observing karyotype dynamics in fully isogenic aneuploid yeast strains with ploidies between 1N...

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Plos Genetics : the Tissue-specific Rna Binding Protein T-star Con...

By: Wendy A. Bickmore

Description : The RNA binding protein T-STAR was created following a gene triplication 520–610 million years ago, which also produced its two parologs Sam68 and SLM-1. Here we have created a T-STAR null mouse to identify the endogenous functions of this RNA binding protein. Mice null for T-STAR developed normally and were fertile, surprisingly, given the high expression of TSTAR in the testis and the brain, and the known infertility and pleiotropic defects of Sam68 null ...

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