World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : an Increase in Mitochondrial Dna Promotes Nuclear Dna Replication in Yeast, Volume 4

By Cohen-fix, Orna

Click here to view

Book Id: WPLBN0003925887
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : an Increase in Mitochondrial Dna Promotes Nuclear Dna Replication in Yeast, Volume 4  
Author: Cohen-fix, Orna
Volume: Volume 4
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection, PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Cohen-Fix, O. (n.d.). Plos Genetics : an Increase in Mitochondrial Dna Promotes Nuclear Dna Replication in Yeast, Volume 4. Retrieved from http://www.nationalpubliclibrary.com/


Description
Description : Coordination between cellular metabolism and DNA replication determines when cells initiate division. It has been assumed that metabolism only plays a permissive role in cell division. While blocking metabolism arrests cell division, it is not known whether an up-regulation of metabolic reactions accelerates cell cycle transitions. Here, we show that increasing the amount of mitochondrial DNA accelerates overall cell proliferation and promotes nuclear DNA replication, in a nutrientdependent manner. The Sir2p NAD+-dependent de-acetylase antagonizes this mitochondrial role. We found that cells with increased mitochondrial DNA have reduced Sir2p levels bound at origins of DNA replication in the nucleus, accompanied with increased levels of K9, K14-acetylated histone H3 at those origins. Our results demonstrate an active role of mitochondrial processes in the control of cell division. They also suggest that cellular metabolism may impact on chromatin modifications to regulate the activity of origins of DNA replication.

 

Click To View

Additional Books


  • Plos Genetics : Variation, Sex, and Soci... (by )
  • Plos Genetics : Adaptive Evolution in Zi... (by )
  • Plos Genetics : Increased Maternal Genom... (by )
  • Plos Genetics : Identification of Orch3,... (by )
  • Plos Genetics : Association of Ncf2, Ikz... (by )
  • Plos Genetics : Histone H2B Monoubiquiti... (by )
  • Plos Genetics : Atypical at Skew in Firm... (by )
  • Plos Genetics : on the Analysis of Genom... (by )
  • Plos Genetics : a Conserved Developmenta... (by )
  • Plos Genetics : an Epigenetic Switch Inv... (by )
  • Plos Genetics : a Highly Redundant Gene ... (by )
  • Plos Genetics : Charcot-marie-tooth–link... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from National Public Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.