World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : Drosophilahistone Deacetylase-3 Controls Imaginal Disc Size Through Suppression of Apoptosis, Volume 4

By Hawley, R. Scott

Click here to view

Book Id: WPLBN0003925944
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : Drosophilahistone Deacetylase-3 Controls Imaginal Disc Size Through Suppression of Apoptosis, Volume 4  
Author: Hawley, R. Scott
Volume: Volume 4
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection, PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Hawley, R. S. (n.d.). Plos Genetics : Drosophilahistone Deacetylase-3 Controls Imaginal Disc Size Through Suppression of Apoptosis, Volume 4. Retrieved from http://www.nationalpubliclibrary.com/


Description
Description : Histone deacetylases (HDACs) execute biological regulation through post-translational modification of chromatin and other cellular substrates. In humans, there are eleven HDACs, organized into three distinct subfamilies. This large number of HDACs raises questions about functional overlap and division of labor among paralogs. In vivo roles are simpler to address in Drosophila, where there are only five HDAC family members and only two are implicated in transcriptional control. Of these two, HDAC1 has been characterized genetically, but its most closely related paralog, HDAC3, has not. Here we describe the isolation and phenotypic characterization of hdac3 mutations. We find that both hdac3 and hdac1 mutations are dominant suppressors of position effect variegation, suggesting functional overlap in heterochromatin regulation. However, all five hdac3 loss-of-function alleles are recessive lethal during larval/pupal stages, indicating that HDAC3 is essential on its own for Drosophila development. The mutant larvae display small imaginal discs, which result from abnormally elevated levels of apoptosis. This cell death occurs as a cell-autonomous response to HDAC3 loss and is accompanied by increased expression of the pro-apoptotic gene, hid. In contrast, although HDAC1 mutants also display small imaginal discs, this appears to result from reduced proliferation rather than from elevated apoptosis. The connection between HDAC loss and apoptosis is important since HDAC inhibitors show anticancer activities in animal models through mechanisms involving apoptotic induction. However, the specific HDACs implicated in tumor cell killing have not been identified. Our results indicate that protein deacetylation by HDAC3 plays a key role in suppression of apoptosis in Drosophila imaginal tissue.

 

Click To View

Additional Books


  • Plos Genetics : Dlx and Sp6-9 Control Op... (by )
  • Plos Genetics : Statistical Analysis Rev... (by )
  • Plos Genetics : Meta-analysis of Genome-... (by )
  • Plos Genetics : a Latent Pro-survival Fu... (by )
  • Plos Genetics : Telomere Recombination A... (by )
  • Plos Genetics : an Abundant Evolutionari... (by )
  • Plos Genetics : Sex Chromosome Mosaicism... (by )
  • Plos Genetics : Dep and Afo Regulate Rep... (by )
  • Plos Genetics : Mixed Effects Modeling o... (by )
  • Plos Genetics : Identification of Neural... (by )
  • Plos Genetics : a Genome-wide Associatio... (by )
  • Plos Genetics : Temporal Transcriptional... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from National Public Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.