World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : Differential Regulation of Horizontally Acquired and Core Genome Genes by the Bacterial Modulator H-ns, Volume 5

By Casadesus, Josep

Click here to view

Book Id: WPLBN0003927687
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : Differential Regulation of Horizontally Acquired and Core Genome Genes by the Bacterial Modulator H-ns, Volume 5  
Author: Casadesus, Josep
Volume: Volume 5
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Casadesus, J. (n.d.). Plos Genetics : Differential Regulation of Horizontally Acquired and Core Genome Genes by the Bacterial Modulator H-ns, Volume 5. Retrieved from http://www.nationalpubliclibrary.com/


Description
Description : Horizontal acquisition of DNA by bacteria dramatically increases genetic diversity and hence successful bacterial colonization of several niches, including the human host. A relevant issue is how this newly acquired DNA interacts and integrates in the regulatory networks of the bacterial cell. The global modulator H-NS targets both core genome and HGT genes and silences gene expression in response to external stimuli such as osmolarity and temperature. Here we provide evidence that H-NS discriminates and differentially modulates core and HGT DNA. As an example of this, plasmid R27- encoded H-NS protein has evolved to selectively silence HGT genes and does not interfere with core genome regulation. In turn, differential regulation of both gene lineages by resident chromosomal H-NS requires a helper protein : the Hha protein. Tight silencing of HGT DNA is accomplished by H-NS-Hha complexes. In contrast, core genes are modulated by H-NS homoligomers. Remarkably, the presence of Hha-like proteins is restricted to the Enterobacteriaceae. In addition, conjugative plasmids encoding H-NS variants have hitherto been isolated only from members of the family. Thus, the H-NS system in enteric bacteria presents unique evolutionary features. The capacity to selectively discriminate between core and HGT DNA may help to maintain horizontally transmitted DNA in silent form and may give these bacteria a competitive advantage in adapting to new environments, including host colonization.

 

Click To View

Additional Books


  • Plos Genetics : Parkinson’s Disease–asso... (by )
  • Plos Genetics : Temporal Analysis of Mei... (by )
  • Plos Genetics : Origin-dependent Inverte... (by )
  • Plos Genetics : Genetic Networks of Live... (by )
  • Plos Genetics : Jagged2A-notch Signaling... (by )
  • Plos Genetics : Epigenetic Patterns Main... (by )
  • Plos Genetics : Genome-wide Occupancy of... (by )
  • Plos Genetics : Copy Number Variants and... (by )
  • Plos Genetics : the Caenorhabditis Elega... (by )
  • Plos Genetics : Analysis of Population S... (by )
  • Plos Genetics : an Integrated Approach f... (by )
  • Plos Genetics : Dmyc Functions Downstrea... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from National Public Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.