World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : Evidence for a Xer, Volume 6

By Burkholder, William F.

Click here to view

Book Id: WPLBN0003929649
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : Evidence for a Xer, Volume 6  
Author: Burkholder, William F.
Volume: Volume 6
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Publication Date:
Publisher: Plos


APA MLA Chicago

Burkholder, W. F. (n.d.). Plos Genetics : Evidence for a Xer, Volume 6. Retrieved from

Description : Homologous recombination events between circular chromosomes, occurring during or after replication, can generate dimers that need to be converted to monomers prior to their segregation at cell division. In Escherichia coli, chromosome dimers are converted to monomers by two paralogous site-specific tyrosine recombinases of the Xer family (XerC/D). The Xer recombinases act at a specific dif site located in the replication termination region, assisted by the cell division protein FtsK. This chromosome resolution system has been predicted in most Bacteria and further characterized for some species. Archaea have circular chromosomes and an active homologous recombination system and should therefore resolve chromosome dimers. Most archaea harbour a single homologue of bacterial XerC/D proteins (XerA), but not of FtsK. Therefore, the role of XerA in chromosome resolution was unclear. Here, we have identified dif-like sites in archaeal genomes by using a combination of modeling and comparative genomics approaches. These sites are systematically located in replication termination regions. We validated our in silico prediction by showing that the XerA protein of Pyrococcus abyssi specifically recombines plasmids containing the predicted dif site in vitro. In contrast to the bacterial system, XerA can recombine dif sites in the absence of protein partners. Whereas Archaea and Bacteria use a completely different set of proteins for chromosome replication, our data strongly suggest that XerA is most likely used for chromosome resolution in Archaea.


Click To View

Additional Books

  • Plos Genetics : the Systemic Imprint of ... (by )
  • Plos Genetics : Foxo Regulates Organ-spe... (by )
  • Plos Genetics : Minibrain, Volume 8 (by )
  • Plos Genetics : Population Structure of ... (by )
  • Plos Genetics : Notch and Prospero Repre... (by )
  • Plos Genetics : the Recombinases Rad51 a... (by )
  • Plos Genetics : Protective Coupling of M... (by )
  • Plos Genetics : the Thermoanaerobacter G... (by )
  • Plos Genetics : Cis- and Trans-acting El... (by )
  • Plos Genetics : a High-density Admixture... (by )
  • Plos Genetics : Genetic Identification o... (by )
  • Plos Genetics : Dna Methylation and Norm... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from National Public Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.