World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : Evidence of Selection Upon Genomic Gc-content in Bacteria, Volume 6

By Nachman, Michael W.

Click here to view

Book Id: WPLBN0003929651
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : Evidence of Selection Upon Genomic Gc-content in Bacteria, Volume 6  
Author: Nachman, Michael W.
Volume: Volume 6
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Nachman, M. W. (n.d.). Plos Genetics : Evidence of Selection Upon Genomic Gc-content in Bacteria, Volume 6. Retrieved from http://www.nationalpubliclibrary.com/


Description
Description : The genomic GC-content of bacteria varies dramatically, from less than 20% to more than 70%. This variation is generally ascribed to differences in the pattern of mutation between bacteria. Here we test this hypothesis by examining patterns of synonymous polymorphism using datasets from 149 bacterial species. We find a large excess of synonymous GCRAT mutations over ATRGC mutations segregating in all but the most AT-rich bacteria, across a broad range of phylogenetically diverse species. We show that the excess of GCRAT mutations is inconsistent with mutation bias, since it would imply that most GC-rich bacteria are declining in GC-content: such a pattern would be unsustainable. We also show that the patterns are probably not due to translational selection or biased gene conversion, because optimal codons tend to be AT-rich, and the excess of GCRAT SNPs is observed in datasets with no evidence of recombination. We therefore conclude that there is selection to increase synonymous GC-content in many species. Since synonymous GC-content is highly correlated to genomic GC-content, we further conclude that there is selection on genomic base composition in many bacteria.

 

Click To View

Additional Books


  • Plos Genetics : Nuc2P, a Subunit of the ... (by )
  • Plos Genetics : Replication Timing of Hu... (by )
  • Plos Genetics : Srf1 is a Novel Regulato... (by )
  • Plos Genetics : Genome-wide Expression P... (by )
  • Plos Genetics : Epigenetic and Conventio... (by )
  • Plos Genetics : Dynamic Chromatin Organi... (by )
  • Plos Genetics : Spreading of Heterochrom... (by )
  • Plos Genetics : Adaptive Copy Number Evo... (by )
  • Plos Genetics : Histone Deacetylase 2 Hd... (by )
  • Plos Genetics : Phenome-wide Association... (by )
  • Plos Genetics : Multiple Loci Within the... (by )
  • Plos Genetics : Glucocorticoid Receptor-... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from National Public Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.