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Plos Genetics : Identification of Genes Required for Neural-specific Glycosylation Using Functional Genomics, Volume 6

By Perrimon, Norbert

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Book Id: WPLBN0003929727
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : Identification of Genes Required for Neural-specific Glycosylation Using Functional Genomics, Volume 6  
Author: Perrimon, Norbert
Volume: Volume 6
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection, PLoS Genetics
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Publisher: Plos

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Perrimon, N. (n.d.). Plos Genetics : Identification of Genes Required for Neural-specific Glycosylation Using Functional Genomics, Volume 6. Retrieved from http://www.nationalpubliclibrary.com/


Description
Description : Glycosylation plays crucial regulatory roles in various biological processes such as development, immunity, and neural functions. For example, a1,3-fucosylation, the addition of a fucose moiety abundant in Drosophila neural cells, is essential for neural development, function, and behavior. However, it remains largely unknown how neural-specific a1,3-fucosylation is regulated. In the present study, we searched for genes involved in the glycosylation of a neural-specific protein using a Drosophila RNAi library. We obtained 109 genes affecting glycosylation that clustered into nine functional groups. Among them, members of the RNA regulation group were enriched by a secondary screen that identified genes specifically regulating a1,3-fucosylation. Further analyses revealed that an RNA–binding protein, second mitotic wave missing (Swm), upregulates expression of the neural-specific glycosyltransferase FucTA and facilitates its mRNA export from the nucleus. This first large-scale genetic screen for glycosylation-related genes has revealed novel regulation of fucTA mRNA in neural cells.

 

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