World Library  

Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : the Tale Class Homeobox Gene Smed-prepdefines the Anterior Compartment for Head Regeneration, Volume 6

By Mango, Susan E.

Click here to view

Book Id: WPLBN0003929901
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : the Tale Class Homeobox Gene Smed-prepdefines the Anterior Compartment for Head Regeneration, Volume 6  
Author: Mango, Susan E.
Volume: Volume 6
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection, PLoS Genetics
Publication Date:
Publisher: Plos


APA MLA Chicago

Mango, S. E. (n.d.). Plos Genetics : the Tale Class Homeobox Gene Smed-prepdefines the Anterior Compartment for Head Regeneration, Volume 6. Retrieved from

Description : Planaria continue to blossom as a model system for understanding all aspects of regeneration. They provide an opportunity to understand how the replacement of missing tissues from preexisting adult tissue is orchestrated at the molecular level. When amputated along any plane, planaria are capable of regenerating all missing tissue and rescaling all structures to the new size of the animal. Recently, rapid progress has been made in understanding the developmental pathways that control planarian regeneration. In particular Wnt/beta-catenin signaling is central in promoting posterior fates and inhibiting anterior identity. Currently the mechanisms that actively promote anterior identity remain unknown. Here, Smed-prep, encoding a TALE class homeodomain, is described as the first gene necessary for correct anterior fate and patterning during planarian regeneration. Smed-prep is expressed at high levels in the anterior portion of whole animals, and Smed-prep(RNAi) leads to loss of the whole brain during anterior regeneration, but not during lateral regeneration or homeostasis in intact worms. Expression of markers of different anterior fated cells are greatly reduced or lost in Smed-prep(RNAi) animals. We find that the ectopic anterior structures induced by abrogation of Wnt signaling also require Smed-prep to form. We use double knockdown experiments with the S. mediterranea ortholog of nou-darake (that when knocked down induces ectopic brain formation) to show that Smed-prep defines an anterior fated compartment within which stem cells are permitted to assume brain fate, but is not required directly for this differentiation process. Smed-prep is the first gene clearly implicated as being necessary for promoting anterior fate and the first homeobox gene implicated in establishing positional identity during regeneration. Together our results suggest that Smed-prep is required in stem cell progeny as they form the anterior regenerative blastema and is required for specifying anterior cell fates and correct patterning.


Click To View

Additional Books

  • Plos Genetics : Effect of Correlated Trn... (by )
  • Plos Genetics : an Als-linked Mutant Sod... (by )
  • Plos Genetics : a Systems Genetics Appro... (by )
  • Plos Genetics : a Genetic Basis for a Po... (by )
  • Plos Genetics : a Genome-wide Analysis o... (by )
  • Plos Genetics : Instability of Plastid D... (by )
  • Plos Genetics : Repression of Germline R... (by )
  • Plos Genetics : Tinkering Evolution of P... (by )
  • Plos Genetics : Diverse Chromatin Remode... (by )
  • Plos Genetics : Genome-wide Association ... (by )
  • Plos Genetics : Recombination Dynamics o... (by )
  • Plos Genetics : Optimal Strategy for Com... (by )
Scroll Left
Scroll Right


Copyright © World Library Foundation. All rights reserved. eBooks from National Public Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.