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Plos Genetics : Integrating 5-hydroxymethylcytosine Into the Epigenomic Landscape of Human Embryonic Stem Cells, Volume 7

By Pearson, Christopher E.

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Book Id: WPLBN0003931693
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : Integrating 5-hydroxymethylcytosine Into the Epigenomic Landscape of Human Embryonic Stem Cells, Volume 7  
Author: Pearson, Christopher E.
Volume: Volume 7
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

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Pearson, C. E. (n.d.). Plos Genetics : Integrating 5-hydroxymethylcytosine Into the Epigenomic Landscape of Human Embryonic Stem Cells, Volume 7. Retrieved from http://www.nationalpubliclibrary.com/


Description
Description : Covalent modification of DNA distinguishes cellular identities and is crucial for regulating the pluripotency and differentiation of embryonic stem (ES) cells. The recent demonstration that 5-methylcytosine (5-mC) may be further modified to 5-hydroxymethylcytosine (5-hmC) in ES cells has revealed a novel regulatory paradigm to modulate the epigenetic landscape of pluripotency. To understand the role of 5-hmC in the epigenomic landscape of pluripotent cells, here we profile the genome-wide 5-hmC distribution and correlate it with the genomic profiles of 11 diverse histone modifications and six transcription factors in human ES cells. By integrating genomic 5-hmC signals with maps of histone enrichment, we link particular pluripotency-associated chromatin contexts with 5-hmC. Intriguingly, through additional correlations with defined chromatin signatures at promoter and enhancer subtypes, we show distinct enrichment of 5-hmC at enhancers marked with H3K4me1 and H3K27ac. These results suggest potential role(s) for 5-hmC in the regulation of specific promoters and enhancers. In addition, our results provide a detailed epigenomic map of 5-hmC from which to pursue future functional studies on the diverse regulatory roles associated with 5-hmC.

 

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