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Plos Genetics : Mu Insertions Are Repaired by the Double-strand Break Repair Pathway of Escherichia Coli, Volume 8

By Hughes, Diarmaid

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Book Id: WPLBN0003941936
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : Mu Insertions Are Repaired by the Double-strand Break Repair Pathway of Escherichia Coli, Volume 8  
Author: Hughes, Diarmaid
Volume: Volume 8
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

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Hughes, D. (n.d.). Plos Genetics : Mu Insertions Are Repaired by the Double-strand Break Repair Pathway of Escherichia Coli, Volume 8. Retrieved from http://www.nationalpubliclibrary.com/


Description
Description : Mu is both a transposable element and a temperate bacteriophage. During lytic growth, it amplifies its genome by replicative transposition. During infection, it integrates into the Escherichia coli chromosome through a mechanism not requiring extensive DNA replication. In the latter pathway, the transposition intermediate is repaired by transposasemediated resecting of the 59 flaps attached to the ends of the incoming Mu genome, followed by filling the remaining 5 bp gaps at each end of the Mu insertion. It is widely assumed that the gaps are repaired by a gap-filling host polymerase. Using the E. coli Keio Collection to screen for mutants defective in recovery of stable Mu insertions, we show in this study that the gaps are repaired by the machinery responsible for the repair of double-strand breaks in E. coli—the replication restart proteins PriA-DnaT and homologous recombination proteins RecABC. We discuss alternate models for recombinational repair of the Mu gaps.

 

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