World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos Genetics : Polycomb Controls Gliogenesis by Regulating the Transient Expression of the Gcm, Volume 8

By Auld, Vanessa

Click here to view

Book Id: WPLBN0003941959
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos Genetics : Polycomb Controls Gliogenesis by Regulating the Transient Expression of the Gcm, Volume 8  
Author: Auld, Vanessa
Volume: Volume 8
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection (Contemporary), PLoS Genetics
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Auld, V. (n.d.). Plos Genetics : Polycomb Controls Gliogenesis by Regulating the Transient Expression of the Gcm, Volume 8. Retrieved from http://www.nationalpubliclibrary.com/


Description
Description : The Gcm/Glide transcription factor is transiently expressed and required in the Drosophila nervous system. Threshold Gcm/ Glide levels control the glial versus neuronal fate choice, and its perdurance triggers excessive gliogenesis, showing that its tight and dynamic regulation ensures the proper balance between neurons and glia. Here, we present a genetic screen for potential gcm/glide interactors and identify genes encoding chromatin factors of the Trithorax and of the Polycomb groups. These proteins maintain the heritable epigenetic state, among others, of HOX genes throughout development, but their regulatory role on transiently expressed genes remains elusive. Here we show that Polycomb negatively affects Gcm/Glide autoregulation, a positive feedback loop that allows timely accumulation of Gcm/Glide threshold levels. Such temporal finetuning of gene expression tightly controls gliogenesis. This work performed at the levels of individual cells reveals an undescribed mode of Polycomb action in the modulation of transiently expressed fate determinants and hence in the acquisition of specific cell identity in the nervous system.

 

Click To View

Additional Books


  • Plos Genetics : Genetic Determinants of ... (by )
  • Plos Genetics : Reductive Genome Evoluti... (by )
  • Plos Genetics : Structural Model Analysi... (by )
  • Plos Genetics : Ancient and Recent Adapt... (by )
  • Plos Genetics : Osd1 Promotes Meiotic Pr... (by )
  • Plos Genetics : Oncogenic Pathway Combin... (by )
  • Plos Genetics : a Cis-acting Diversifica... (by )
  • Plos Genetics : Computational Identifica... (by )
  • Plos Genetics : Horizontally Acquired Gl... (by )
  • Plos Genetics : Bmp4is Essential for the... (by )
  • Plos Genetics : Uncoupling Antisense-med... (by )
  • Plos Genetics : Inactivation of Vcp, Vol... (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from National Public Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.