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Plos Genetics : the Caenorhabditis Elegans Jnk Signaling Pathway Activates Expression of Stress Response Genes by Derepressing the Fos, Volume 9

By Garsin, Danielle A.

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Book Id: WPLBN0003953197
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Genetics : the Caenorhabditis Elegans Jnk Signaling Pathway Activates Expression of Stress Response Genes by Derepressing the Fos, Volume 9  
Author: Garsin, Danielle A.
Volume: Volume 9
Language: English
Subject: Journals, Science, Genetics
Collections: Periodicals: Journal and Magazine Collection, PLoS Genetics
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Publisher: Plos

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Garsin, D. A. (n.d.). Plos Genetics : the Caenorhabditis Elegans Jnk Signaling Pathway Activates Expression of Stress Response Genes by Derepressing the Fos, Volume 9. Retrieved from http://www.nationalpubliclibrary.com/


Description
Description : MAP kinases are integral to the mechanisms by which cells respond to a wide variety of environmental stresses. In Caenorhabditis elegans, the KGB-1 JNK signaling pathway regulates the response to heavy metal stress. In this study, we identified FOS-1, a bZIP transcription factor, as a target of KGB-1-mediated phosphorylation. We further identified two transcriptional targets of the KGB-1 pathway, kreg-1 and kreg-2/lys-3, which are required for the defense against heavy metal stress. FOS-1 plays a critical role in the transcriptional repression of the kreg-1 gene by recruiting histone deacetylase (HDAC) to its promoter. KGB-1 phosphorylation prevents FOS-1 dimerization and promoter binding, resulting in promoter derepression. Thus, HDAC behaves as a co-repressor modulating FOS-1-mediated transcriptional regulation. This study describes the direct link from JNK signaling, Fos phosphorylation, and regulation of kreg gene transcription, which modulates the stress response in C. elegans.

 

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